Mast Sunil Gavandgare 9yr male presented to ENT OPD - Fauziya Nursing Home, Kurla with symptoms of copious watery ear (right) discharge like a tap of water once or twice in a week from three to four months. No H/O - Head injury General and ENT examination revealed no abnormality. Patient's ear discharge (fluid) microscopic and biochemical analysis showed inconclusive findings.

Mast. Salman - 3 days old infant - resident of vapi hospitalized in fauziya Nursing home N.I.C.U with stridor (Noisy breathing), chest indrawing and cynosis. Child was immediately intubated and oxygenated and kept on ventilator.

Child had undergone tracheostomy. Child was treated with Panaceand Videolaryngoscopy revealed bilateral congenital abductor vocal cord palsy. Child needed artificial ventilation for seven days.

Child was transferred to Vapi under ENT surgeon's care. Child started breathing of his own and did not require artificial ventilation. Child was continued on panaceand treatment.

Child was examined endoscopically and both vocal cords were functioning. Child's tracheostomy tube was removed observed for twenty four hrs. It was uneventful.

Presented to ENT - OPD Fauziya Nursing Home on 12/03/2003 with staccatospeech, delayed mile stones and unsteadiness, incordination of hand / leg movements, stepping gait .Inability to stand and walk without support since birth. H/antipsychotic drugs - given 2 yrs ago for one year.

On Gen. Exam:
Conscious, co-operative, thin build incoherent eye movements, strain full and staccato speech. Hypersalivation

CNS	-	Comprehension is satisfactory.
Eye	-	Pendular eye movements (Nystagmus) Asynchronous with other eye. Pupllary reaction and fundoscopy = N AD
Gait	-	stepping gait .Movements -neuromuscular incordination, Tremors - Overshooting action.

Previous Investigations

Irregular in treatment .50-60% clinical improvement and speech performance. Advised to continue same

80% clinical improvement able to walk without support needs support while climbing staircase. Pendular nystagmus reduced by 50%
Conclusion: Extremely satisfactory clinical improvement.

Mr. Narayan Chormole , twenty year male presented to ENT OPD with severe pain in left submandibular region with diffuse swelling and induration in neck. Similar episodes in past. There was no stridor. Examination confirms diagnosis of Ludwig's angina secondary to submandibular sialolithiasis (salivary stone) and sialoadenitis. He was treated with tab panaceand and oral antibiotics

Third day, stone of 1.7x1.3cm size extruded out. Extrusion of stone against gravity is a unique experience. The swelling subsided without surgical intervention. Panaceand one tab twice a day is continued to prevent recurrent sialolithiasis. To the best of our knowledge and belief this type of incidence is unreported in world literature.

A 20yr male presented with stridor (Noisy breathing) at rest and hoarseness of voice, inability to sleep .He had a cut throat injury three months ago for which he had undergone tracheostomy and repair at other centre. He was decanulated successfully after one month. A month later he started getting stridor, breathlessness, inability to sleep, hoarseness of voice. ..etc...
Phonation duration was 3to 4- sec.

Diagnostic video- optical laryngoscopy revealed laryngeal tilt and bilateral. vocal cord fixation.
His HRCT scan of larynx revealed findings of laryngeal stenosis. (Photo).
He was put on tab panaceand thrice daily.

Mohbbat Ali 7yr old presented to ENT OPD with huge mass rt.upper jaw with facial swelling. He was unable to close his mouth. Mass use to bleed when he was trying to close the mouth. C.T.Scan done one month ago with contrast enhancement proved angiofibroma involving rt .upper jaw and rt.maxillary sinus. He had undergone laser assisted excision at some other centre. Excisional biopsy proved angiofibroma. Mass recurred to same extent within span of fifteen days.

Child was hospitalised. Patient was put on panaceand two tablets three times a day. Within span of seven days his bleeding stopped .Mass started regressing. He was taken up for surgery keeping two points of cross matched and compatible blood ready.

His rt external carotid artery was ligated. He had undergone rt. subtotal maxillectomy by sublabial midfacial degloving approach with primary palatobuccal closure followed by dental rehabilitation. Histolosgical study reconfirmed the diagnosis of aggressive angiofibroma. Post operatively he was advised to have one tablet twice daily for five years.

A thirty two years old male K/c of diabetes since five years, have been treated with oral hypoglycaemic and diabetic diet. Presented with difficulty in griping footwear since one year, tingling numbness and altered sensations in both lower extremities. Clinical examination revealed blunting of pain, touch, and vibratory sensation, hypoasthesia in extremities, diminished knee and ankle jerks, postural hypotension.

Sixty years old male presented with painful multiple vesicular lesions in supraclavicular region extending to shoulder with constitutional symptoms like fever, malaise, myalgia, anorexia, and headache since fifteen days.

Clinical examination: There was evidence of multiple vesicular lesions with erythematous base associated with shallow ulcerative lesions as shown in fig…..

Treatment: Patient was treated with tablet Panaceand two tablets thrice daily for seven days. He was isolated for seven days. Then one tablet twice daily for next fifteen days.

Result: Constitutional symptoms disappeared within two days. Vesicular lesion dissolved and scab developed within seven days. Scabs were replaced by faint scars subsequently.

Symptoms never recurred (neuralgic pain). Patient is asymptomatic since then.

Thirteen years old female patient presented with frequent episodes of typical itchy erythematous papules over the forearms, hands and face; parts exposed to sunlight more in the summer since 3 - 4 years. She was treated by dermatologist but she was not responding to conventional line of treatment.

Treatment: She was treated with tablet Panaceand two tabs twice daily for fifteen days.

Result: She responded to Panaceand treatment within fifteen days. Subsequent exposure to sunlight did not show any clinical sign and symptom.

Mast. Mohammad Sohil Khan 3years old , resident of Kurla , mobile no. 9821787811/3279800 was brought to ENT OPD by his parents with tongue-tie with developmental childhood dyspraxia (inability to speak ) .Child's crying and babbling developed normally, speech inception was very late. The consonant and vowel production was grossly deviant in expression of words. Words expressed by child were very unclear and strainful.
Parents were attributing his speech problems to tongue-tie. They thought that release of tongue-tie will solve this problem permanently. Parents were explained that problem is located in speech centre in brain and releasing tongue-tie is going to contribute very little to the entire solution. : Child was put on tab. Panaceand one tablet twice daily

Child started uttering clear words within ten days of therapy; without even assisted speech therapy.

Conclusion: Panaceand is very effective in treating neurogenic developmental disorders. Children respond much faster than adults.

15years old girl presented to ENT clinic with left ear discharge since childhood. She had loss of hearing of right ear since last five years following to operation.
ENT examination revealed left ear CSOM with cholesteatoma and right ear healthy mastoid cavity. Left ear was the only functioning ear. She was scheduled for left ear modified radical matoidectomy under local anaesthesia.
Postoperatively there was no lateralization to left ear on Weber's test. There was strong suspicion of right ear profound hearing loss.
Pure tone audiometry done on seventh postoperative day revealed profound sensorineural loss. fifteenth day of panaceand treatment, two tablets thrice daily. Left ear hearing started recovering. She resumed her normal left ear hearing within twenty one days.

Conclusion: Panaceand is an excellent neuro-regenerative agent if started in appropriate time.